WebFactor H is a member of the regulators of complement activation family and is a complement control protein.It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at typical concentrations of 200–300 micrograms per milliliter).Its principal function is to regulate the alternative pathway of the complement system, ensuring that … WebDec 6, 2015 · Ajona and colleagues showed that a combination of antibodies to CFH and CD59 increased CDC of A549 and H1264 NSCLC cell lines over that seen with anti-CFH antibody alone. Although the full extent of the humoral response to TAAs remains to be defined, prior studies with circulating antibodies against Her2/neu in breast cancer …
Complement Factor H Antibodies from Lung Cancer Patients …
WebCFH is a membrane cofactor protein, variation in which is associated with a number of diseases such as age-related macular degeneration, kidney disorder and C3 glomerulopathy. The penetrance is found to be low in many diseases. [ 2] CFH might prevent complement activation in ischaemic renal injury by binding to tubular epithelial … WebMay 17, 2016 · In an effort to translate these findings into a biologic therapy for cancer, we isolated and expressed DNA sequences encoding high-affinity human CFH antibodies directly from single, sorted B cells obtained from patients with the antibody. The co-crystal structure of a CFH antibody-target complex shows a conformational change in the target ... keyboard f functions
Complement Factor H Monoclonal Antibody (OX-24)
WebApr 14, 2024 · The complement system is crucial for immune surveillance, providing the body’s first line of defence against pathogens. However, an imbalance in its regulators can lead to inappropriate overactivation, resulting in diseases such as age-related macular degeneration (AMD), a leading cause of irreversible blindness globally affecting … WebThe antibody detects endogenous level of total CFH antibody. Applications WB Reactivity Human Immunogen Recombinant protein of human CFH. Host Rabbit Clonality … WebMar 21, 2024 · CFH (Complement Factor H) is a Protein Coding gene. Diseases associated with CFH include Complement Factor H Deficiency and Hemolytic Uremic … keyboard f buttons