Cisplatin binding to holliday junction
WebPMID: 9535214 Abstract Proteins that can be shown to strongly bind in vitro to the four-way (Holliday) junction DNA include not only the obvious candidates such as enzymes involved in recombination, but also a remarkably diverse group of seemingly unrelated proteins. WebApr 3, 2007 · The bifunctional binding of the anticancer drug cisplatin to two adjacent nucleobases in DNA is modeled using density functional theory. Previous experimental studies revealed that cisplatin binding to adjacent guanine and adenine is sensitive to nucleobase sequence.
Cisplatin binding to holliday junction
Did you know?
Webway DNA structure, also called a Holliday junction, which is processed by the RuvABC proteins.2 The RuvA protein initially binds the Holliday junction, and then recruits RuvB protein rings to opposite sides of the junction.3,4 RuvB is a molecular motor that uses the energy derived from ATP binding and hydrolysis to drive unidirectional movement ... WebFeb 21, 1997 · The E. coli RuvA and RuvB proteins, which are involved in the late stages of recombination and the recombinational repair of damaged DNA, bind to Holliday junctions and promote branch migration. We have used electron microscopy and image analysis to examine RuvA and RuvB bound to model Holliday structures.
WebJul 11, 2000 · Actually, both of the RuvA tetramers, the upper and the lower, simultaneously contact each strand of a DNA duplex arm ( 16 ). By contrast, in complex I, the two … WebConformational switching of the synthetic Holliday junction (HJ) labeled with a Cy3-Cy5 fluorophore pair. (b) Representative single molecule fluorescence-time traces from our …
WebTo expose two cut sites, the Holliday junction is rotated by 180° to form a sequare planar structure. Resolution of Holliday junction occurs by cutting the DNA strands at the site of cross and re-joining them. Resolution occurs in one of the two ways. This gives rise to two classes of DNA products. WebHolliday junctions (Holliday, 1964) are four-way junctions in DNA formed by the mutual exchange of strand connectivity, and thus connected by the covalent continuity of each strand of the junction ( Orr-Weaver, Szostak, & Rothstein, 1981; Potter & Dressler, 1976; Schwacha & Kleckner, 1995 ).
WebIt has been found that Thermus thermophilus RuvC (TthRuvC) binds specifically to an unstacked Holliday junction and cuts selective DNA sequence, while poxvirus HJ resolvase does not have strong...
shang properties inc addressWebAug 27, 2024 · Brogden, A.L.; Hopcroft, N.H.; Searcey, M.; Cardin, C.J. Ligand bridging of the DNA Holliday junction: Molecular recognition of a stacked-X four-way junction by a … shang properties inc careersWebJul 5, 2024 · Holliday junctions (HJs) are an important class of nucleic acid structure utilized in DNA break repair processes. As such, these structures have great importance as therapeutic targets and for... shang priestWebOct 5, 2014 · 1. Introduction. Cisplatin (CAS No. 15663-27-1, MF-Cl 2 H 6 N 2 Pt; NCF-119875), cisplatinum, also called cis-diamminedichloroplatinum(II), is a metallic (platinum) coordination compound with a square planar geometry.It is a white or deep yellow to yellow-orange crystalline powder at room temperature. It is slightly soluble in water and soluble … shangpree spa locationsWebMay 15, 2007 · This binding mode is specific for the Holliday junction and does not cause unwinding of the DNA helices. Citing Literature Supporting Information Volume 46, Issue … shangpree marine jewel capsuleWebStudy with Quizlet and memorize flashcards containing terms like The zipper-like connection between paired homologs in early prophase is known as a, Crossing-over takes place in bivalents (tetrads) consisting of ______ chromatids, and one crossover involves _______ chromatids., Which type of tetrad contains two recombinant and two parental … shang properties inc stock priceWebThe BCDX2 complex also bound to the synthetic Holliday junction, and its af®nity to the Holliday-junction DNA was signi®cantly higher than that of Rad51B (Fig. 4). shang properties inc annual report