WebDec 16, 2024 · The heterogeneity of the subgroup of creatinine clearance in Leu 2024 was due to the fact that patients received an unusual dose of cisplatin (cisplatin, 40 mg/m 2) and mannitol (12.5 g). While 89 patients received 25 g of mannitol and 6 received 12.5 g in Williams 2016, the different doses of mannitol may be the reason for the heterogeneity of ... WebMeasurements of Blood Urea Nitrogen (BUN), serum creatinine and creatinine clearance should be taken before initiating cisplatin therapy, and prior to subsequent doses, as toxicity is cumulative. Cisplatin is recommended to be given once every 3-4 weeks. Hydration is recommended to minimise nephrotoxicity.
Oncological outcomes of dose reductions in cisplatin due to …
Webcisplatin is 75 mg/m2 BSA infused over two hours approximately 30 minutes after completion of the pemetrexed infusion on the first day of each 21-day cycle. Patients must receive adequate anti-emetic ... creatinine clearance of ≥ 45 ml/min required no dose adjustments other than those recommended for all patients. There are insufficient data ... WebJan 11, 2024 · Cisplatin-induced nephrotoxicity can also recover to some degree over time. Following 3–5 cycles of cisplatin at doses of 100–200 mg/m 2 (total cumulative dose … church in constantinople
Cisplatin (Cisplatin Injection): Uses, Dosage, Side Effects ... - RxList
WebSep 18, 2024 · Cisplatin can be used as monotherapy or as part of a multi-drug regimen. Patients should have proper hydration while monitoring urine output before, during, and for 24 hours following administration. Renal … WebCreatinine clearance ( CrCl) is an estimate of Glomerular Filtration Rate ( GFR ); however, CrCl is slightly higher than true GFR because creatinine is secreted by the proximal tubule (in addition to being filtered by the glomerulus). The additional proximal tubule secretion falsely elevates the CrCl estimate of GFR. 12 WebMar 9, 2024 · Currently, societies of nephrology recommend dose reductions in cisplatin for patients with renal insufficiency of creatinine clearance (CrCl) between 30 and 60 mL/min. 10 - 12 Among their recommendations, unified protocol based on Kintzel's indication is especially popular. 10, 11, 13 Kintzel et al reported an indicator of cisplatin dose … church in porterville