Cpwwp2a

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August undefined, 2024

WebMay 16, 2024 · For example, circRNA cPWWP2A could upregulate the expression of occludin, angiopoietin-1, and sirtuin-1 (markers regulating retinal vascularization and endothelial cell function), thereby ... WebMar 26, 2024 · Knockout of cPWWP2A and mimicking its downstream target miR579 could further increase the number of avascular zone, pericyte loss and microangioma. later, they found that overexpression of cPWWP2A ...

Targeting pericyte–endothelial cell crosstalk by circular …

WebMay 16, 2024 · Search life-sciences literature (41,842,822 articles, preprints and more) Search. Advanced search WebDexamethasone (DEX) induces significant cytotoxicity to human osteoblasts. cPWWP2A is recently-indentified novel circular RNA (circRNA), acting as an endogenous sponge of microRNA-579 (miR-579). The present study tested the expression and potential functions of the cPWWP2A-miR-579 axis in DEX-treated osteoblasts. We show that cPWWP2A is … scleroderma disease icd 10

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WebMar 1, 2024 · We show that cPWWP2A is downregulated in the necrotic femoral head tissues of DEX-taking human patients as well as in DEX-treated human osteoblasts. In OB-6 osteoblastic cells and primary human osteoblasts ectopic overexpression of cPWWP2A potently inhibited DEX-induced miR-579 accumulation, cell death, apoptosis and … WebNational Center for Biotechnology Information WebJan 3, 2024 · Recent studies have shown that exosomes can influence the course of NLRP3 inflammasome-associated diseases by secreting different substances that affect key … prayers for peace in time of war

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Dysregulation of cPWWP2A-miR-579 axis mediates ... - ScienceDirect

WebMar 17, 2024 · These results suggest that cPWWP2A is a molecular sponge for miR-29b. To verify that cPWWP2A/miR-29b regulates the NLRP3 signaling pathway, C2C12 cells … WebOct 7, 2016 · We show that cPWWP2A is downregulated in the necrotic femoral head tissues of DEX-taking human patients as well as in DEX-treated human osteoblasts. In OB-6 osteoblastic cells and primary human osteoblasts ectopic overexpression of cPWWP2A potently inhibited DEX-induced miR-579 accumulation, cell death, apoptosis and … scleroderma disease bob sagetWebgulated cPWWP2A leads to abnormal pericyte–EC crosstalk in vitro and retinal vascular dysfunction in vivo, suggesting that cPWWP2A is an important regulator in diabetes … prayers for pet healing

"WebPart C - Employee (To be completed by the employee if not employed with the Federal Government at the time of the claimed recurrence) 1. For all jobs held since you left the … " - Cpwwp2a

Cpwwp2a

WebDec 3, 2024 · CPWWP2A-miR-579 interaction in DR. Dysregulated functions of retinal microvasculature that comprise endothelial cells and pericytes have been reported to be a major cause of vascular leakage in patients with DR.94 An elevated expression of cPWWP2A in pericytes was reported by Liu et al. in 2024, suggesting their role in DR. … WebIn addition, silencing cPWWP2A also exacerbated retinal inflammation (Liu et al., 2024). Mechanistically, cPWWP2A acting as a miRNA sponge sequesters and inhibits the activity of miR-579, thereby upregulating the expression of target genes of miR-579 including angiopoietin 1, occludin, and SIRT1 in pericytes (Liu et al., 2024).

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WebSep 24, 2024 · Significantly, forced overexpression of cPWWP2A largely attenuated DEX-induced cytotoxicity in OB-6 cells (Fig. 2 C–E). Download : Download high-res image … Web“cPWWP2A-miR-579-Angiopoietin 1/Occluding/SIRT1” in DR. This study may provide new insight into the potential use the cPWWP2A-miR-579 as new treatment strategies for DR. Although the quick development of high-throughput RNA deep sequencing, along with bioinformatics predictor tools, will enable a faster discovery of the pathway interac-

WebIt is shown that diabetes-related stress up-regulates cPWWP2A expression in pericytes but not in ECs, and a mechanism by which pericyte and ECs communicate is unveiled, which may offer opportunities for treating diabetic microvascular complications. Significance The crosstalk between vascular endothelial cells (ECs) and pericytes in the microvascular is … WebMar 1, 2024 · In addition, cPWWP2A inhibited the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway through the miR-29b/ CDK6 axis in C2C12 cells (Wang et al., 2024b). In another research, UMSC-Exos could ...

WebMar 26, 2024 · The sequence of cPWWP2A obtained by Sanger sequencing was consistent with the sequence of cPWWP2A annotated in circBase (Fig. 1B). cPWWP2A was … WebJul 1, 2024 · Request PDF Dysregulation of cPWWP2A-miR-579 axis mediates dexamethasone-induced cytotoxicity in human osteoblasts Dexamethasone (DEX) induces significant cytotoxicity to human osteoblasts ...

Web“cPWWP2A-miR-579-Angiopoietin 1/Occluding/SIRT1” in DR. This study may provide new insight into the potential use the cPWWP2A-miR-579 as new treatment strategies for …

WebEVs enriched in cPWWP2A, with high affinity for miRNA-579, and normalized retinal microvascular function , while miRNA-202-5p-loaded EVs inhibited cell proliferation, migration, and vascularization . In rats, EVs from adipose-derived MSCs loaded with miRNA-192 relieved DR-associated inflammation and pathologic angiogenesis . prayers for our military and veteransWebMar 28, 2024 · Abstract A few studies suggested that CircRNAs were involved in the development of septic AKI. However，the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we fou... prayers for peace memeWebNov 17, 2024 · The downregulation of circRNA DMNT3B expression contributes to diabetic retinal vascular dysfunction by targeting miR-20b-5p and BAMBI . cPWWP2A regulates pericyte biology, and cPWWP2A overexpression alleviates diabetes-induced retinal vascular dysfunction . Nevertheless, the potential functions of circRNAs and the related … scleroderma disease in the lungsWebMar 26, 2024 · cPWWP2A regulates retinal pericyte function and pericyte–EC crosstalk in vitro. (A and B) Pericytes were transfected with scrambled (Scr) siRNA, cPWWP2A … prayers for persecuted believersWebMar 17, 2024 · The link between cPWWP2A and miR-29b was confirmed by dual-luciferase assays showing a strong binding of miR-29b to cPWWP2A (Fig. (Fig.1l). 1l). The expression of miR-29b was increased in ischemic muscle (Supplementary Fig. 9a), which was contrary to that of cPWWP2A. These results suggest that cPWWP2A is a molecular sponge for … scleroderma early skin symptomsWebApr 9, 2024 · By contrast, inhibition of cPWWP2A-mediated signaling by silencing cPWWP2A or overexpressing miR-579 aggravates retinal vascular dysfunction. … scleroderma earsWebMar 21, 2024 · Protein attributes for PWWP2A Gene. Size: 755 amino acids. Molecular mass: 81960 Da. Protein existence level: PE1. Quaternary structure: Component of a … prayers for people in hospital