Dynein light intermediate chain binding

Author: arzf

August undefined, 2024

Web1 day ago · Additionally, to the HC, there are several light and intermediate chains present in the ODA and IDA, alongside with light-intermediate chains for the IDA. ... Step 2: The β-HC, from helical bundle 5 to the β-dynein head, shifts slightly. The two binding partners LC3 and the α kelch domain move with the β-tail. Step 3: The stalk and MTBD of ... WebJan 1, 2024 · The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proc. Natl. Acad. Sci. U.S.A., 104 (2007), ... The …

Amrita Kumari - UMass Chan Medical School - LinkedIn

WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated … WebMar 7, 2024 · Dynein is a 1.4 MDa homodimeric complex of two heavy chains, which each binds smaller subunits, including the intermediate chain, light intermediate chain, and three light chains. how device tree talks with device drivers

The dynein light chain 8 binding motif of rabies virus …

WebThe light intermediate chains associate in the dynein complex only as homoligomers. b ... LC4/Ca+2 binding: Related protein: ... Dynein is part of a complex including dynein … Web1 day ago · Additionally, to the HC, there are several light and intermediate chains present in the ODA and IDA, alongside with light-intermediate chains for the IDA. ... Step 2: … WebAug 1, 2011 · Cytoplasmic dynein consists of heavy chain (HC), intermediate chain (IC), light IC (LIC), and light chain (LC) subunits, ... The 8-kDa dynein light chain binds to … how many rounds mtg

Structure of the dynein-2 complex and its assembly …

NIH 3D - Dynein light intermediate chain region of the dynein …

WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in maintaining cellular homeostasis is unknown. WebAug 30, 2024 · Further, we noticed that the N-terminus of kazrin C shares homology with dynein/dynactin adaptors and that it directly interacts with the dynactin complex and the dynein Light Intermediate Chain 1 (LIC1). Altogether, the data indicate that one of the primary kazrin functions is to facilitate endocytic recycling via the perinuclear endocytic ... how developed is ukraineWebJun 1, 2002 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: microtubule motor activity Source:UniProtKB. 1 publication. ... Consists of at least two heavy chains and a number of intermediate and light chains. Protein-protein interaction databases. BioGRID. 120722 7 interactors; IntAct. Q8TD57 6 … how many rounds is there in the fa cup

"WebAug 26, 2024 · Binding of one dynein-2 complex to the train creates extra binding ... Hou, Y., Pazour, G. J. & Witman, G. B. A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar ... " - Dynein light intermediate chain binding

Dynein light intermediate chain binding

DYNC1LI2 regulates localization of the chaperone-mediated …

WebMar 30, 2024 · The light-intermediate chain has a Ras-like fold and appears to bind to nucleotides (Schroeder et al., 2014; Toropova et al., 2024). Although nucleotide-binding by the light-intermediate chain does not seem essential for dynein-2 function (Hou et al., 2004), whether it serves a structural role or has a minor regulatory function remains unclear. WebSpindly’s N-terminal coiled-coil uses distinct motifs to bind dynein light intermediate chain and the pointed-end complex of dynactin. Mutations in these motifs inhibit assembly of a dynein–dynactin–Spindly complex, and a null mutant of the dynactin pointed-end subunit p27 prevents kinetochore recruitment of dynein–dynactin without ...

Did you know?

WebOct 1, 2014 · The LIC domain structure has interesting parallels with the dynein intermediate chain, which has a well-ordered WD repeat … WebRefSeq Summary (NM_001145154): Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major …

WebCytoplasmic dynein and dynactin are megadalton-sized multisubunit molecules that function together as a cytoskeletal motor. In the present study, we explore the mechanism of dynein-dynactin binding in vitro and then extend our findings to an in vivo context. Solution binding assays were used to define binding domains in the dynein intermediate chain (IC) and … WebMay 1, 2024 · Presumably to accommodate its very broad range of activities, a variety of dynein “cargo”-binding mechanisms have evolved. In some cases, dynein-cargo associations are mediated directly by the cytoplasmic dynein intermediate or light intermediate chain subunits [[2], [3], [4]].

Web13411 Ensembl ENSG00000105877 ENSMUSG00000018581 UniProt Q96DT5 n/a RefSeq (mRNA) NM_001277115 NM_010060 RefSeq (protein) NP_001264044 n/a Location (UCSC) Chr 7: 21.54 – 21.9 Mb Chr 12: 117.84 – 118.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dynein axonemal heavy chain 11 (DNAH11), is a … WebMar 4, 2024 · The cytoplasmic dynein light intermediate chains (LICs) 1 and 2 are cargo-binding subunits, though their relative roles are not well understood. Here, we used in …

WebMar 29, 2024 · The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016] Other designations. …

WebMar 7, 2002 · Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell 2011, 22 (15) , 2690-2701. DOI: 10.1091/mbc.e11-01-0075. ... The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proceedings of the National ... how devops supports cloud native approachWebMar 4, 2024 · Coil: yellow. Ribbons are thickened and non-physical struts added to make more robust for 3D printing. 6f1y-ribbon-rainbow-vis. Molecular ribbon representation with each biopolymer chain colored by rainbow from N-terminus (red) to C-terminus (blue). Intended for visualization only, not 3D printing. how many rounds is tyson fightWebOct 1, 2014 · Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we have determined the crystal structure of the conserved LIC domain, which binds the motor heavy chain, from a thermophilic fungus. We show that … how many rounds of family feudWebShop Target Dulles Store for furniture, electronics, clothing, groceries, home goods and more at prices you will love. how many rounds of bhastrika are thereWebMay 15, 2024 · The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which … how many rounds of chemo before hair lossWebRefSeq Summary (NM_001145154): Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by … how many rounds is the nfl draftWebWestin Hotels Near Ashburn The Westin Washington Dulles Airport. 4.7 miles from Ashburn Rooms from $197 2520 Wasser Terrace - Herndon. The Westin Reston Heights how dewey decimal system works